Assay Detail
Binding
CHEMBL923037
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Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cells
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M5 (CHEMBL2035) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.29 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1162116 | — | — | 1 | 8.21 |
| CHEMBL21536 | XANOMELINE | 4.0 | 1 | 7.82 |
| CHEMBL77793 | — | — | 1 | 7.29 |
| CHEMBL151938 | MILAMELINE | 2.0 | 1 | 5.50 |
| CHEMBL259662 | — | — | 1 | 5.43 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.37 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 4.99 |
| CHEMBL259344 | — | — | 1 | 4.99 |
| CHEMBL258907 | — | — | 1 | 4.97 |
| CHEMBL320820 | — | — | 1 | 4.88 |
| CHEMBL105457 | — | — | 1 | 4.66 |
| CHEMBL402473 | — | — | 1 | 4.64 |
| CHEMBL258906 | — | — | 1 | 4.63 |
| CHEMBL258905 | — | — | 1 | 4.61 |
| CHEMBL541424 | — | — | 2 | 4.47 |
| CHEMBL259131 | — | — | 1 | 4.28 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1162116 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL21536 | XANOMELINE | Ki | = | 15.14 | nM | 7.82 |
| CHEMBL77793 | — | Ki | = | 51.29 | nM | 7.29 |
| CHEMBL151938 | MILAMELINE | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL259662 | — | Ki | = | 3715.35 | nM | 5.43 |
| CHEMBL14 | CARBACHOL | Ki | = | 4265.8 | nM | 5.37 |
| CHEMBL550 | PILOCARPINE | Ki | = | 10232.93 | nM | 4.99 |
| CHEMBL259344 | — | Ki | = | 10232.93 | nM | 4.99 |
| CHEMBL258907 | — | Ki | = | 10715.19 | nM | 4.97 |
| CHEMBL320820 | — | Ki | = | 13182.57 | nM | 4.88 |
| CHEMBL105457 | — | Ki | = | 21877.62 | nM | 4.66 |
| CHEMBL402473 | — | Ki | = | 22908.68 | nM | 4.64 |
| CHEMBL258906 | — | Ki | = | 23442.29 | nM | 4.63 |
| CHEMBL258905 | — | Ki | = | 24547.09 | nM | 4.61 |
| CHEMBL541424 | — | Ki | = | 33884.42 | nM | 4.47 |
| CHEMBL259131 | — | Ki | = | 52480.75 | nM | 4.28 |
| CHEMBL7303 | ARECOLINE | Ki | = | 56234.13 | nM | 4.25 |
| CHEMBL541424 | — | Ki | = | 57543.99 | nM | 4.24 |