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Assay Detail

CHEMBL923739

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Binding
Inhibition of Photinus pyralis luciferase
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Photinus pyralis
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Luciferin 4-monooxygenase (CHEMBL5567) ↗
Type SINGLE PROTEIN
Organism Photinus pyralis

Publication

Characterization of chemical libraries for luciferase inhibitory activity.
Auld DS, Southall NT, Jadhav A, Johnson RL, Diller DJ, Simeonov A, Austin CP, Inglese J.
J Med Chem (2008) 51 : 2372 -2386
PubMed 18363348 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 45 6.21 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL406835 — — 1 7.30
CHEMBL405914 — — 1 7.10
CHEMBL258888 — — 1 7.10
CHEMBL265686 — — 1 7.00
CHEMBL405317 — — 1 7.00
CHEMBL473735 — — 1 6.82
CHEMBL261123 — — 1 6.82
CHEMBL264931 (R)-INDOPROFEN — 1 6.70
CHEMBL264933 — — 1 6.68
CHEMBL259805 — — 1 6.66
CHEMBL374632 — — 1 6.62
CHEMBL260451 — — 1 6.52
CHEMBL259422 — — 1 6.52
CHEMBL259615 — — 1 6.52
CHEMBL198759 — — 1 6.50
CHEMBL261118 — — 1 6.40
CHEMBL259103 — — 1 6.40
CHEMBL259784 — — 1 6.39
CHEMBL260560 — — 1 6.30
CHEMBL408653 — — 1 6.30
CHEMBL428789 — — 1 6.22
CHEMBL407501 — — 1 6.22
CHEMBL260342 — — 1 6.19
CHEMBL265715 — — 1 6.16
CHEMBL259460 — — 1 6.16
CHEMBL354261 — — 1 6.10
CHEMBL328710 — — 1 6.10
CHEMBL260028 — — 1 6.08
CHEMBL410484 — — 1 6.05
CHEMBL406557 — — 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL406835 — IC50 = 50.0 nM 7.30
CHEMBL405914 — IC50 = 80.0 nM 7.10
CHEMBL258888 — IC50 = 80.0 nM 7.10
CHEMBL265686 — IC50 = 100.0 nM 7.00
CHEMBL405317 — IC50 = 100.0 nM 7.00
CHEMBL473735 — IC50 = 150.0 nM 6.82
CHEMBL261123 — IC50 = 150.0 nM 6.82
CHEMBL264931 (R)-INDOPROFEN IC50 = 200.0 nM 6.70
CHEMBL264933 — IC50 = 210.0 nM 6.68
CHEMBL259805 — IC50 = 220.0 nM 6.66
CHEMBL374632 — IC50 = 240.0 nM 6.62
CHEMBL259422 — IC50 = 300.0 nM 6.52
CHEMBL259615 — IC50 = 300.0 nM 6.52
CHEMBL260451 — IC50 = 300.0 nM 6.52
CHEMBL198759 — IC50 = 320.0 nM 6.50
CHEMBL261118 — IC50 = 400.0 nM 6.40
CHEMBL259103 — IC50 = 400.0 nM 6.40
CHEMBL259784 — IC50 = 410.0 nM 6.39
CHEMBL260560 — IC50 = 500.0 nM 6.30
CHEMBL408653 — IC50 = 500.0 nM 6.30
CHEMBL428789 — IC50 = 600.0 nM 6.22
CHEMBL407501 — IC50 = 600.0 nM 6.22
CHEMBL260342 — IC50 = 650.0 nM 6.19
CHEMBL259460 — IC50 = 700.0 nM 6.16
CHEMBL265715 — IC50 = 700.0 nM 6.16
CHEMBL354261 — IC50 = 800.0 nM 6.10
CHEMBL328710 — IC50 = 800.0 nM 6.10
CHEMBL260028 — IC50 = 840.0 nM 6.08
CHEMBL410484 — IC50 = 900.0 nM 6.05
CHEMBL406557 — IC50 = 1000.0 nM 6.00
CHEMBL258889 — IC50 = 1000.0 nM 6.00
CHEMBL267160 — IC50 = 1100.0 nM 5.96
CHEMBL260213 — IC50 = 1100.0 nM 5.96
CHEMBL444376 — IC50 = 1100.0 nM 5.96
CHEMBL408850 — IC50 = 1200.0 nM 5.92
CHEMBL259421 — IC50 = 1300.0 nM 5.89
CHEMBL1200712 EVANS BLUE IC50 = 1700.0 nM 5.77
CHEMBL408563 — IC50 = 2000.0 nM 5.70
CHEMBL429335 — IC50 = 3200.0 nM 5.50
CHEMBL411085 — IC50 = 4000.0 nM 5.40
CHEMBL88612 — IC50 = 4300.0 nM 5.37
CHEMBL88553 — IC50 = 4500.0 nM 5.35
CHEMBL406368 — IC50 = 4500.0 nM 5.35
CHEMBL66654 — IC50 = 4700.0 nM 5.33
CHEMBL35482 — IC50 = 6200.0 nM 5.21