Compound Detail
CHEMBL411085
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Basic Information
| ChEMBL ID | CHEMBL411085 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BESCHBVTVJFEFE-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
409.5
MW (Da)
3.96
ALogP
5
HBA
0
HBD
62.2
PSA (Ų)
0.51
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Luciferin 4-monooxygenase CHEMBL5567 | IC50 | 5.4 | 5.3725 | 4000.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Luciferin 4-monooxygenase | IC50 | = | 4000.0 | nM | 5.4 | Inhibition of Photinus pyralis luciferase | 18363348 |
| Luciferin 4-monooxygenase | IC50 | = | 4000.0 | nM | 5.4 | Inhibition of adenylate binding site of Photinus pyralis luciferase by quantitat... | 19215089 |
| Luciferin 4-monooxygenase | IC50 | = | 4500.0 | nM | 5.35 | Inhibition of Photinus pyralis luciferase by PK-Light assay | 18363348 |
| Luciferin 4-monooxygenase | IC50 | = | 4600.0 | nM | 5.34 | Inhibition of Photinus pyralis luciferase by Easy lite assay | 18363348 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18363348 | 10.1021/jm701302v | Luciferin 4-monooxygenase | 5 |
| 18363348 | 10.1021/jm701302v | Unchecked | 2 |
| 19215089 | 10.1021/jm8014525 | Luciferin 4-monooxygenase | 2 |
Data from ChEMBL 36 via Core Engine