Assay Detail
Binding
CHEMBL923743
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Inhibition of Photinus pyralis luciferase by BrightGlo reporter gene assay
45
Total Activities
45
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Photinus pyralis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of chemical libraries for luciferase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.61 | 7.10 |
| Activity | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258888 | — | — | 1 | 7.10 |
| CHEMBL406835 | — | — | 1 | 7.05 |
| CHEMBL405914 | — | — | 1 | 6.70 |
| CHEMBL265686 | — | — | 1 | 6.70 |
| CHEMBL473735 | — | — | 1 | 6.52 |
| CHEMBL405317 | — | — | 1 | 6.52 |
| CHEMBL261123 | — | — | 1 | 6.52 |
| CHEMBL374632 | — | — | 1 | 6.40 |
| CHEMBL198759 | — | — | 1 | 6.22 |
| CHEMBL259422 | — | — | 1 | 6.16 |
| CHEMBL264933 | — | — | 1 | 6.16 |
| CHEMBL259784 | — | — | 1 | 6.00 |
| CHEMBL408563 | — | — | 1 | 5.92 |
| CHEMBL408653 | — | — | 1 | 5.92 |
| CHEMBL259805 | — | — | 1 | 5.85 |
| CHEMBL260451 | — | — | 1 | 5.72 |
| CHEMBL88553 | — | — | 1 | 5.70 |
| CHEMBL354261 | — | — | 1 | 5.58 |
| CHEMBL259103 | — | — | 1 | 5.58 |
| CHEMBL260213 | — | — | 1 | 5.50 |
| CHEMBL258889 | — | — | 1 | 5.44 |
| CHEMBL260028 | — | — | 1 | 5.41 |
| CHEMBL260342 | — | — | 1 | 5.40 |
| CHEMBL264931 | (R)-INDOPROFEN | — | 1 | 5.28 |
| CHEMBL408850 | — | — | 1 | 5.23 |
| CHEMBL259615 | — | — | 1 | 5.19 |
| CHEMBL260560 | — | — | 1 | 5.17 |
| CHEMBL259460 | — | — | 1 | 5.14 |
| CHEMBL407501 | — | — | 1 | 5.08 |
| CHEMBL328710 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258888 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL406835 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL265686 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL405914 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL473735 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL405317 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL261123 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL374632 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL198759 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL259422 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL264933 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL259784 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL408563 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL408653 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL259805 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL260451 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL88553 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL354261 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL259103 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL260213 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL258889 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL260028 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL260342 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL264931 | (R)-INDOPROFEN | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL408850 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL259615 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL260560 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL259460 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL407501 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL328710 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL428789 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL429335 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL406557 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL267160 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL444376 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL1200712 | EVANS BLUE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL88612 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL66654 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL35482 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL406368 | — | Activity | - | — | - | |
| CHEMBL411085 | — | Activity | - | — | - | |
| CHEMBL410484 | — | Activity | - | — | - | |
| CHEMBL259421 | — | Activity | - | — | - | |
| CHEMBL261118 | — | Activity | - | — | - | |
| CHEMBL265715 | — | Activity | - | — | - |