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Assay Detail

CHEMBL923873

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]RTI55 from SERT in rat brain synaptosomes
ChEMBL ↗
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Brain
Subcellular Synaptosomes
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Sodium-dependent serotonin transporter (CHEMBL313) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods.
Gilbert KM, Boos TL, Dersch CM, Greiner E, Jacobson AE, Lewis D, Matecka D, Prisinzano TE, Zhang Y, Rothman RB, Rice KC, Venanzi CA.
Bioorg Med Chem (2007) 15 : 1146 -1159
PubMed 17127069 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 48 6.74 8.53

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL27748 — — 1 8.53
CHEMBL286949 — — 1 8.52
CHEMBL252759 — — 1 7.82
CHEMBL429492 — — 1 7.66
CHEMBL28660 — — 1 7.52
CHEMBL255054 — — 1 7.50
CHEMBL429840 — — 1 7.32
CHEMBL434093 — — 1 7.29
CHEMBL28414 — — 1 7.24
CHEMBL136154 — — 1 7.07
CHEMBL538405 — — 1 7.06
CHEMBL28867 — — 1 6.95
CHEMBL160073 — — 1 6.92
CHEMBL281594 VANOXERINE 3.0 1 6.90
CHEMBL286991 — — 1 6.87
CHEMBL255065 — — 1 6.87
CHEMBL289013 — — 1 6.79
CHEMBL136249 — — 1 6.79
CHEMBL34032 — — 1 6.77
CHEMBL409161 — — 1 6.70
CHEMBL284096 — — 1 6.69
CHEMBL416409 — — 1 6.64
CHEMBL34591 — — 1 6.62
CHEMBL285673 — — 1 6.62
CHEMBL159982 — — 1 6.61
CHEMBL36419 — — 1 6.61
CHEMBL137020 — — 1 6.61
CHEMBL34372 — — 1 6.61
CHEMBL28897 — — 1 6.58
CHEMBL35045 — — 1 6.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL27748 — Ki = 2.96 nM 8.53
CHEMBL286949 — Ki = 3.0 nM 8.52
CHEMBL252759 — Ki = 15.19 nM 7.82
CHEMBL429492 — Ki = 22.0 nM 7.66
CHEMBL28660 — Ki = 30.0 nM 7.52
CHEMBL255054 — Ki = 32.0 nM 7.50
CHEMBL429840 — Ki = 48.13 nM 7.32
CHEMBL434093 — Ki = 51.0 nM 7.29
CHEMBL28414 — Ki = 57.0 nM 7.24
CHEMBL136154 — Ki = 85.0 nM 7.07
CHEMBL538405 — Ki = 88.0 nM 7.06
CHEMBL28867 — Ki = 112.0 nM 6.95
CHEMBL160073 — Ki = 119.0 nM 6.92
CHEMBL281594 VANOXERINE Ki = 126.0 nM 6.90
CHEMBL255065 — Ki = 136.0 nM 6.87
CHEMBL286991 — Ki = 135.0 nM 6.87
CHEMBL289013 — Ki = 161.0 nM 6.79
CHEMBL136249 — Ki = 164.0 nM 6.79
CHEMBL34032 — Ki = 171.0 nM 6.77
CHEMBL409161 — Ki = 199.0 nM 6.70
CHEMBL284096 — Ki = 205.0 nM 6.69
CHEMBL416409 — Ki = 229.0 nM 6.64
CHEMBL34591 — Ki = 238.0 nM 6.62
CHEMBL285673 — Ki = 239.0 nM 6.62
CHEMBL159982 — Ki = 243.0 nM 6.61
CHEMBL34372 — Ki = 248.0 nM 6.61
CHEMBL36419 — Ki = 245.0 nM 6.61
CHEMBL137020 — Ki = 246.0 nM 6.61
CHEMBL28897 — Ki = 261.0 nM 6.58
CHEMBL35045 — Ki = 266.0 nM 6.58
CHEMBL403575 — Ki = 266.0 nM 6.58
CHEMBL164270 — Ki = 286.0 nM 6.54
CHEMBL163272 — Ki = 312.0 nM 6.51
CHEMBL251242 — Ki = 338.0 nM 6.47
CHEMBL35411 — Ki = 370.0 nM 6.43
CHEMBL290799 — Ki = 387.0 nM 6.41
CHEMBL35122 — Ki = 442.0 nM 6.36
CHEMBL164297 — Ki = 485.0 nM 6.31
CHEMBL159445 — Ki = 495.0 nM 6.30
CHEMBL28935 — Ki = 525.0 nM 6.28
CHEMBL163163 — Ki = 550.5 nM 6.26
CHEMBL254843 — Ki = 598.0 nM 6.22
CHEMBL36141 — Ki = 606.0 nM 6.22
CHEMBL400707 — Ki = 888.0 nM 6.05
CHEMBL29000 — Ki = 970.0 nM 6.01
CHEMBL255055 — Ki = 1650.0 nM 5.78
CHEMBL28726 — Ki = 1693.0 nM 5.77
CHEMBL252758 — Ki = 2090.0 nM 5.68