Assay Detail
Binding
CHEMBL924758
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Inhibition of GST tagged c-Met expressed in Sf9 cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.10 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402792 | — | — | 1 | 7.62 |
| CHEMBL254760 | — | — | 1 | 7.54 |
| CHEMBL402036 | — | — | 1 | 7.32 |
| CHEMBL258185 | — | — | 1 | 7.31 |
| CHEMBL258240 | — | — | 1 | 7.29 |
| CHEMBL258453 | — | — | 1 | 7.28 |
| CHEMBL254964 | — | — | 1 | 7.27 |
| CHEMBL257987 | — | — | 1 | 7.22 |
| CHEMBL404639 | — | — | 1 | 7.21 |
| CHEMBL256786 | — | — | 1 | 7.20 |
| CHEMBL402550 | — | — | 1 | 7.19 |
| CHEMBL256974 | — | — | 1 | 7.19 |
| CHEMBL258396 | — | — | 1 | 7.16 |
| CHEMBL402004 | — | — | 1 | 7.16 |
| CHEMBL403747 | — | — | 1 | 7.13 |
| CHEMBL438877 | — | — | 1 | 7.10 |
| CHEMBL404495 | — | — | 1 | 6.97 |
| CHEMBL256972 | — | — | 1 | 6.95 |
| CHEMBL402504 | — | — | 1 | 6.94 |
| CHEMBL257802 | — | — | 1 | 6.94 |
| CHEMBL404881 | — | — | 1 | 6.92 |
| CHEMBL402042 | — | — | 1 | 6.90 |
| CHEMBL401838 | — | — | 1 | 6.90 |
| CHEMBL257546 | — | — | 1 | 6.89 |
| CHEMBL256920 | — | — | 1 | 6.89 |
| CHEMBL256715 | — | — | 1 | 6.88 |
| CHEMBL256767 | — | — | 1 | 6.74 |
| CHEMBL254761 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402792 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL254760 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL402036 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL258185 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL258240 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL258453 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL254964 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL257987 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL404639 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL256786 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL402550 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL256974 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL258396 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL402004 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL403747 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL438877 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL404495 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL256972 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL402504 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL257802 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL404881 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL402042 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL401838 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL257546 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL256920 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL256715 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL256767 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL254761 | — | IC50 | = | 193.0 | nM | 6.71 |