Compound Detail
CHEMBL254964
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O=C(Cc1ccccc1)NC(=S)Nc1ccc(Oc2ccnc3cc(C(=O)N4CCCC4)sc23)c(F)c1
Basic Information
| ChEMBL ID | CHEMBL254964 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JTRYIRPUUMAXSL-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
534.6
MW (Da)
5.52
ALogP
6
HBA
2
HBD
83.6
PSA (Ų)
0.32
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 8.05 | 8.05 | 9.0 | 1 |
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 7.27 | 7.27 | 54.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 9.0 | nM | 8.05 | Inhibition of GST tagged VEGFR2 expressed in Sf9 cells | 18434145 |
| Hepatocyte growth factor receptor | IC50 | = | 54.0 | nM | 7.27 | Inhibition of GST tagged c-Met expressed in Sf9 cells | 18434145 |
| Hepatocyte growth factor receptor | IC50 | = | 54.0 | nM | 7.27 | Inhibition of human c-MET | 21641696 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18434145 | 10.1016/j.bmcl.2008.04.009 | Hepatocyte growth factor receptor | 1 |
| 18434145 | 10.1016/j.bmcl.2008.04.009 | Vascular endothelial growth factor receptor 2 | 1 |
| 21641696 | 10.1016/j.ejmech.2011.05.031 | Hepatocyte growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine