Assay Detail
Binding
CHEMBL925405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in IMR32 cells
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Heteroatom-linked indanylpyrazines are corticotropin releasing factor type-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 62 | 6.41 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398531 | — | — | 1 | 7.96 |
| CHEMBL248785 | — | — | 1 | 7.66 |
| CHEMBL251200 | — | — | 1 | 7.66 |
| CHEMBL398258 | — | — | 1 | 7.52 |
| CHEMBL250282 | — | — | 1 | 7.46 |
| CHEMBL248996 | — | — | 1 | 7.29 |
| CHEMBL250814 | — | — | 1 | 7.28 |
| CHEMBL248803 | — | — | 1 | 7.24 |
| CHEMBL250617 | — | — | 1 | 7.23 |
| CHEMBL250815 | — | — | 1 | 7.17 |
| CHEMBL400082 | — | — | 1 | 7.09 |
| CHEMBL250616 | — | — | 1 | 6.94 |
| CHEMBL398843 | — | — | 1 | 6.67 |
| CHEMBL251397 | — | — | 1 | 6.65 |
| CHEMBL401327 | — | — | 1 | 6.60 |
| CHEMBL398425 | — | — | 1 | 6.58 |
| CHEMBL249430 | — | — | 1 | 6.47 |
| CHEMBL250618 | — | — | 1 | 6.42 |
| CHEMBL401295 | — | — | 1 | 6.40 |
| CHEMBL251199 | — | — | 1 | 6.36 |
| CHEMBL402717 | — | — | 1 | 6.34 |
| CHEMBL430019 | — | — | 1 | 6.33 |
| CHEMBL400156 | — | — | 1 | 6.29 |
| CHEMBL449657 | — | — | 1 | 6.28 |
| CHEMBL400154 | — | — | 1 | 6.15 |
| CHEMBL250615 | — | — | 1 | 5.93 |
| CHEMBL249212 | — | — | 1 | 5.92 |
| CHEMBL400155 | — | — | 1 | 5.92 |
| CHEMBL251006 | — | — | 1 | 5.92 |
| CHEMBL248577 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398531 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL248785 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL251200 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL398258 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL250282 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL248996 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL250814 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL248803 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL250617 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL250815 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL400082 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL250616 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL398843 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL251397 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL401327 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL398425 | — | Ki | = | 266.0 | nM | 6.58 |
| CHEMBL249430 | — | Ki | = | 337.0 | nM | 6.47 |
| CHEMBL250618 | — | Ki | = | 384.0 | nM | 6.42 |
| CHEMBL401295 | — | Ki | = | 401.0 | nM | 6.40 |
| CHEMBL251199 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL402717 | — | Ki | = | 456.0 | nM | 6.34 |
| CHEMBL430019 | — | Ki | = | 472.0 | nM | 6.33 |
| CHEMBL400156 | — | Ki | = | 509.0 | nM | 6.29 |
| CHEMBL449657 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL400154 | — | Ki | = | 711.0 | nM | 6.15 |
| CHEMBL250615 | — | Ki | = | 1185.0 | nM | 5.93 |
| CHEMBL400155 | — | Ki | = | 1207.0 | nM | 5.92 |
| CHEMBL251006 | — | Ki | = | 1217.0 | nM | 5.92 |
| CHEMBL249212 | — | Ki | = | 1208.0 | nM | 5.92 |
| CHEMBL248577 | — | Ki | = | 1261.0 | nM | 5.90 |
| CHEMBL248585 | — | Ki | = | 1540.0 | nM | 5.81 |
| CHEMBL400952 | — | Ki | = | 1733.0 | nM | 5.76 |
| CHEMBL251034 | — | Ki | = | 2021.0 | nM | 5.69 |
| CHEMBL248623 | — | Ki | = | 2123.0 | nM | 5.67 |
| CHEMBL398300 | — | Ki | = | 2376.0 | nM | 5.62 |
| CHEMBL248816 | — | Ki | = | 2434.0 | nM | 5.61 |
| CHEMBL248588 | — | Ki | = | 2703.0 | nM | 5.57 |
| CHEMBL400531 | — | Ki | = | 3382.0 | nM | 5.47 |
| CHEMBL249191 | — | Ki | = | 3980.0 | nM | 5.40 |
| CHEMBL249012 | — | Ki | = | 4688.0 | nM | 5.33 |
| CHEMBL399877 | — | Ki | = | 5473.0 | nM | 5.26 |
| CHEMBL251204 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL248784 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL251007 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL398365 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL250653 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL399936 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL251198 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL250680 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL401297 | — | Ki | > | 10000.0 | nM | - |