Compound Detail
CHEMBL400531
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Basic Information
| ChEMBL ID | CHEMBL400531 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NHLUIFIKRDTBRC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
327.5
MW (Da)
4.65
ALogP
5
HBA
2
HBD
62.7
PSA (Ų)
0.74
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | Ki | 5.47 | 5.47 | 3382.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | Ki | = | 3382.0 | nM | 5.47 | Displacement of [125I]Tyr-o-CRF from CRF1 receptor in IMR32 cells | 17888659 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17888659 | 10.1016/j.bmcl.2007.09.008 | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine