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Assay Detail

CHEMBL925438

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of AChE by Ellman method
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Acetylcholinesterase (CHEMBL220)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase.
Wang YH, Zhang ZK, Yang FM, Sun QY, He HP, Di YT, Mu SZ, Lu Y, Chang Y, Zheng QT, Ding M, Dong JH, Hao XJ.
J Nat Prod (2007) 70 : 1458 -1461
PubMed 17822295 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.88 7.00
Activity 3 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1524 SANGUININE 1 7.00
CHEMBL95 TACRINE 4.0 1 6.70
CHEMBL251077 1 6.02
CHEMBL659 GALANTAMINE 4.0 1 5.97
CHEMBL1523 NORSANGUININE 1 5.84
CHEMBL409610 1 5.79
CHEMBL252723 1 5.63
CHEMBL479291 UNGEREMINE 1 5.42
CHEMBL402484 ASSOANINE 1 5.41
CHEMBL251076 EPINORGALANTAMINE 1 5.04
CHEMBL401114 (+)-HAEMANTHAMINE 1 -
CHEMBL400092 LYCORINE 1 -
CHEMBL250688 1 -
CHEMBL250866 1 -
CHEMBL465820 1 -
CHEMBL251056 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1524 SANGUININE IC50 = 100.0 nM 7.00
CHEMBL95 TACRINE IC50 = 200.0 nM 6.70
CHEMBL251077 IC50 = 960.0 nM 6.02
CHEMBL659 GALANTAMINE IC50 = 1070.0 nM 5.97
CHEMBL1523 NORSANGUININE IC50 = 1430.0 nM 5.84
CHEMBL409610 IC50 = 1610.0 nM 5.79
CHEMBL252723 IC50 = 2320.0 nM 5.63
CHEMBL479291 UNGEREMINE IC50 = 3850.0 nM 5.42
CHEMBL402484 ASSOANINE IC50 = 3870.0 nM 5.41
CHEMBL251076 EPINORGALANTAMINE IC50 = 9010.0 nM 5.04
CHEMBL401114 (+)-HAEMANTHAMINE IC50 = 452000.0 nM -
CHEMBL400092 LYCORINE IC50 = 155000.0 nM -
CHEMBL250688 IC50 = 113000.0 nM -
CHEMBL250866 Activity - -
CHEMBL465820 Activity - -
CHEMBL251056 Activity - -