Compound Detail
CHEMBL1524
SANGUININE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1524 |
| Name | SANGUININE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OYSGWKOGUVOGFQ-RBOXIYTFSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
273.3
MW (Da)
1.55
ALogP
4
HBA
2
HBD
52.9
PSA (Ų)
0.70
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acetylcholinesterase CHEMBL220 | IC50 | 7.0 | 7.0 | 100.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acetylcholinesterase | IC50 | = | 100.0 | nM | 7.0 | Inhibition of AChE by Ellman method | 17822295 |
| Acetylcholinesterase | IC50 | = | 100.0 | nM | 7.0 | Inhibition of AChE (unknown origin) | 32949964 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17822295 | 10.1021/np0702077 | Acetylcholinesterase | 1 |
| 31515186 | 10.1016/j.bmcl.2019.126642 | Trypanosoma brucei rhodesiense | 1 |
| 31515186 | 10.1016/j.bmcl.2019.126642 | Leishmania donovani | 1 |
| 31515186 | 10.1016/j.bmcl.2019.126642 | Trypanosoma cruzi | 1 |
| 26913788 | 10.1021/acs.jnatprod.5b00681 | RAW264.7 | 1 |
| 26913788 | 10.1021/acs.jnatprod.5b00681 | Acetylcholinesterase | 1 |
| 32949964 | 10.1016/j.ejmech.2020.112792 | Acetylcholinesterase | 1 |
Data from ChEMBL 36 via Core Engine