Assay Detail
Functional
CHEMBL925478
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Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New functional assay of P-glycoprotein activity using Hoechst 33342.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.94 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.31 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.64 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.21 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.03 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 6.93 |
| CHEMBL176049 | RHODAMINE123 | — | 1 | 5.72 |
| CHEMBL343002 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 4.898 | nM | 8.31 |
| CHEMBL107 | COLCHICINE | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 61.66 | nM | 7.21 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 93.33 | nM | 7.03 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 117.49 | nM | 6.93 |
| CHEMBL176049 | RHODAMINE123 | IC50 | = | 1905.46 | nM | 5.72 |
| CHEMBL343002 | — | IC50 | = | 1905.46 | nM | 5.72 |