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Assay Detail

CHEMBL925549

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Functional
Antiproliferative activity against mouse P388 cells by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type P388
Confidence 1 — Organism
Curated By Autocuration

Target

P388 (CHEMBL389)
Type CELL-LINE
Organism Mus musculus

Publication

Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines.
Podeszwa B, Niedbala H, Polanski J, Musiol R, Tabak D, Finster J, Serafin K, Milczarek M, Wietrzyk J, Boryczka S, Mol W, Jampilek J, Dohnal J, Kalinowski DS, Richardson DR.
Bioorg Med Chem Lett (2007) 17 : 6138 -6141
PubMed 17904844 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.11 5.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL250484 1 5.84
CHEMBL250659 1 5.84
CHEMBL224238 1 5.82
CHEMBL224482 1 5.79
CHEMBL250485 1 5.62
CHEMBL388378 1 5.21
CHEMBL402271 1 5.18
CHEMBL248968 1 5.15
CHEMBL241898 1 5.15
CHEMBL225640 1 4.99
CHEMBL250486 1 4.87
CHEMBL400150 1 4.81
CHEMBL248770 1 4.29
CHEMBL400149 1 4.10
CHEMBL248771 1 4.05
CHEMBL446454 1 -
CHEMBL428230 1 -
CHEMBL249172 1 -
CHEMBL248967 1 -
CHEMBL248965 1 -
CHEMBL250487 1 -
CHEMBL250670 1 -
CHEMBL248769 1 -
CHEMBL248772 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL250484 IC50 = 1440.0 nM 5.84
CHEMBL250659 IC50 = 1430.0 nM 5.84
CHEMBL224238 IC50 = 1510.0 nM 5.82
CHEMBL224482 IC50 = 1610.0 nM 5.79
CHEMBL250485 IC50 = 2390.0 nM 5.62
CHEMBL388378 IC50 = 6100.0 nM 5.21
CHEMBL402271 IC50 = 6580.0 nM 5.18
CHEMBL248968 IC50 = 7140.0 nM 5.15
CHEMBL241898 IC50 = 7140.0 nM 5.15
CHEMBL225640 IC50 = 10310.0 nM 4.99
CHEMBL250486 IC50 = 13560.0 nM 4.87
CHEMBL400150 IC50 = 15330.0 nM 4.81
CHEMBL248770 IC50 = 51150.0 nM 4.29
CHEMBL400149 IC50 = 79110.0 nM 4.10
CHEMBL248771 IC50 = 89400.0 nM 4.05
CHEMBL446454 IC50 = 113720.0 nM -
CHEMBL428230 IC50 = 147630.0 nM -
CHEMBL249172 IC50 = 158380.0 nM -
CHEMBL248967 IC50 = 109120.0 nM -
CHEMBL248965 IC50 = 109770.0 nM -
CHEMBL250487 IC50 = 109680.0 nM -
CHEMBL250670 IC50 = 113810.0 nM -
CHEMBL248769 IC50 = 116290.0 nM -
CHEMBL248772 IC50 = 100020.0 nM -