Assay Detail
Binding
CHEMBL925554
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Inhibition of ATP-induced autophosphorylation of cFMS tyrosine kinase in HEK 293 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent 2'-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.26 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249957 | — | — | 1 | 7.12 |
| CHEMBL398933 | — | — | 1 | 6.82 |
| CHEMBL398360 | — | — | 1 | 6.77 |
| CHEMBL398734 | — | — | 1 | 6.75 |
| CHEMBL399542 | — | — | 1 | 6.72 |
| CHEMBL251351 | — | — | 1 | 6.64 |
| CHEMBL400754 | — | — | 1 | 6.60 |
| CHEMBL251602 | — | — | 1 | 6.52 |
| CHEMBL250157 | — | — | 1 | 6.51 |
| CHEMBL249955 | — | — | 1 | 6.48 |
| CHEMBL428056 | — | — | 1 | 6.44 |
| CHEMBL249543 | — | — | 1 | 6.43 |
| CHEMBL249124 | — | — | 1 | 6.43 |
| CHEMBL399543 | — | — | 1 | 6.12 |
| CHEMBL249748 | — | — | 1 | 6.02 |
| CHEMBL250156 | — | — | 1 | 6.00 |
| CHEMBL249330 | — | — | 1 | 5.85 |
| CHEMBL251603 | — | — | 1 | 5.85 |
| CHEMBL250187 | — | — | 1 | 5.70 |
| CHEMBL439233 | — | — | 1 | 5.66 |
| CHEMBL400753 | — | — | 1 | 5.58 |
| CHEMBL249747 | — | — | 1 | 5.57 |
| CHEMBL249749 | — | — | 1 | 5.51 |
| CHEMBL249956 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249957 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL398933 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL398360 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL398734 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL399542 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL251351 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL400754 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL251602 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL250157 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL249955 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL428056 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL249543 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL249124 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL399543 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL249748 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL250156 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL249330 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL251603 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL250187 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL439233 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL400753 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL249747 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL249749 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL249956 | — | IC50 | > | 2000.0 | nM | - |