Compound Detail
CHEMBL249749
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Basic Information
| ChEMBL ID | CHEMBL249749 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GGHFAZMFVKUZNN-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
324.4
MW (Da)
2.85
ALogP
5
HBA
2
HBD
95.3
PSA (Ų)
0.90
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 6.7 | 6.105 | 200.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 200.0 | nM | 6.7 | Inhibition of ATP-induced autophosphorylation of cFMS tyrosine kinase | 17904845 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 3100.0 | nM | 5.51 | Inhibition of ATP-induced autophosphorylation of cFMS tyrosine kinase in HEK 293... | 17904845 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17904845 | 10.1016/j.bmcl.2007.09.057 | Macrophage colony-stimulating factor 1 receptor | 2 |
Data from ChEMBL 36 via Core Engine