Assay Detail
Binding
CHEMBL925553
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Inhibition of ATP-induced autophosphorylation of cFMS tyrosine kinase
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent 2'-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 6.86 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249747 | — | — | 1 | 7.77 |
| CHEMBL249957 | — | — | 1 | 7.77 |
| CHEMBL398360 | — | — | 1 | 7.72 |
| CHEMBL400754 | — | — | 1 | 7.62 |
| CHEMBL399542 | — | — | 1 | 7.60 |
| CHEMBL400753 | — | — | 1 | 7.47 |
| CHEMBL249543 | — | — | 1 | 7.44 |
| CHEMBL250157 | — | — | 1 | 7.43 |
| CHEMBL249955 | — | — | 1 | 7.43 |
| CHEMBL251351 | — | — | 1 | 7.37 |
| CHEMBL398933 | — | — | 1 | 7.33 |
| CHEMBL398734 | — | — | 1 | 7.33 |
| CHEMBL428056 | — | — | 1 | 7.28 |
| CHEMBL251602 | — | — | 1 | 7.11 |
| CHEMBL250156 | — | — | 1 | 7.10 |
| CHEMBL249748 | — | — | 1 | 7.05 |
| CHEMBL399543 | — | — | 1 | 6.92 |
| CHEMBL249330 | — | — | 1 | 6.89 |
| CHEMBL249124 | — | — | 1 | 6.85 |
| CHEMBL249749 | — | — | 1 | 6.70 |
| CHEMBL250187 | — | — | 1 | 6.58 |
| CHEMBL439233 | — | — | 1 | 6.42 |
| CHEMBL251603 | — | — | 1 | 6.41 |
| CHEMBL250188 | — | — | 1 | 6.14 |
| CHEMBL251369 | — | — | 1 | 5.96 |
| CHEMBL399343 | — | — | 1 | 5.96 |
| CHEMBL251157 | — | — | 1 | 5.72 |
| CHEMBL249987 | — | — | 1 | 5.72 |
| CHEMBL251156 | — | — | 1 | 5.36 |
| CHEMBL401198 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249747 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL249957 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL398360 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL400754 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL399542 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL400753 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL249543 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL250157 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL249955 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL251351 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL398933 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL398734 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL428056 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL251602 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL250156 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL249748 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL399543 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL249330 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL249124 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL249749 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL250187 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL439233 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL251603 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL250188 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL399343 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL251369 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL251157 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL249987 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL251156 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL401198 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL250757 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL399130 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL399541 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL250958 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL250959 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL399957 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL249346 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL400123 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL249542 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL249162 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL248959 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL248958 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL251586 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL251575 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL400939 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL249956 | — | IC50 | > | 2000.0 | nM | - |