Compound Detail
CHEMBL249987
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Basic Information
| ChEMBL ID | CHEMBL249987 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OORUPZVGNHKYDK-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
301.3
MW (Da)
3.04
ALogP
5
HBA
1
HBD
88.6
PSA (Ų)
0.69
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.98
IC50 1 meas. best 5.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 6.98 | 5.925 | 105.0 | 2 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 5.72 | 5.72 | 1900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 105.0 | nM | 6.98 | PUBCHEM_BIOASSAY: Luminescence Cell-Based/Microorganism Dose Confirmation HTS to... | - |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 1900.0 | nM | 5.72 | Inhibition of ATP-induced autophosphorylation of cFMS tyrosine kinase | 17904845 |
| Unchecked | EC50 | = | 13541.0 | nM | 4.87 | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS Screen to Identify C... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17904845 | 10.1016/j.bmcl.2007.09.057 | Macrophage colony-stimulating factor 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine