Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL925628

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

N-formyl peptide receptor 2 (CHEMBL4227)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation.
Frohn M, Xu H, Zou X, Chang C, McElvaine M, Plant MH, Wong M, Tagari P, Hungate R, Bürli RW.
Bioorg Med Chem Lett (2007) 17 : 6633 -6637
PubMed 17920884 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 6.00 7.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL249132 1 7.47
CHEMBL379761 1 7.36
CHEMBL248928 1 6.89
CHEMBL249742 1 6.57
CHEMBL250347 1 6.16
CHEMBL249537 1 6.09
CHEMBL400089 1 6.08
CHEMBL404003 1 5.99
CHEMBL249338 1 5.83
CHEMBL251772 1 5.82
CHEMBL400723 1 5.73
CHEMBL401313 1 5.57
CHEMBL401314 1 5.46
CHEMBL250143 1 5.29
CHEMBL430016 1 4.91
CHEMBL249339 1 4.85
CHEMBL377169 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL249132 EC50 = 34.0 nM 7.47
CHEMBL379761 EC50 = 44.0 nM 7.36
CHEMBL248928 EC50 = 130.0 nM 6.89
CHEMBL249742 EC50 = 270.0 nM 6.57
CHEMBL250347 EC50 = 690.0 nM 6.16
CHEMBL249537 EC50 = 810.0 nM 6.09
CHEMBL400089 EC50 = 830.0 nM 6.08
CHEMBL404003 EC50 = 1020.0 nM 5.99
CHEMBL249338 EC50 = 1490.0 nM 5.83
CHEMBL251772 EC50 = 1520.0 nM 5.82
CHEMBL400723 EC50 = 1870.0 nM 5.73
CHEMBL401313 EC50 = 2710.0 nM 5.57
CHEMBL401314 EC50 = 3500.0 nM 5.46
CHEMBL250143 EC50 = 5100.0 nM 5.29
CHEMBL430016 EC50 = 12200.0 nM 4.91
CHEMBL249339 EC50 = 14100.0 nM 4.85
CHEMBL377169 EC50 > 10000.0 nM -