Assay Detail
Binding
CHEMBL925953
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Displacement of [N-methyl-3H]scopolamine from human recombinant muscarinic receptor M1 expressed in CHO cell membrane
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.97 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256121 | — | — | 1 | 7.03 |
| CHEMBL404220 | — | — | 1 | 6.06 |
| CHEMBL257999 | — | — | 1 | 6.02 |
| CHEMBL403553 | — | — | 1 | 5.92 |
| CHEMBL401971 | — | — | 1 | 5.55 |
| CHEMBL256729 | — | — | 1 | 5.25 |
| CHEMBL403408 | — | — | 1 | - |
| CHEMBL257376 | — | — | 1 | - |
| CHEMBL401502 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256121 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL404220 | — | IC50 | = | 862.0 | nM | 6.06 |
| CHEMBL257999 | — | IC50 | = | 954.0 | nM | 6.02 |
| CHEMBL403553 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL401971 | — | IC50 | = | 2804.0 | nM | 5.55 |
| CHEMBL256729 | — | IC50 | = | 5607.0 | nM | 5.25 |
| CHEMBL403408 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL257376 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL401502 | — | IC50 | > | 5000.0 | nM | - |