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Assay Detail

CHEMBL926323

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei brucei bloodstream trypomastigotes by alamar blue assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma brucei brucei (CHEMBL612851)
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds.
Hoet S, Pieters L, Muccioli GG, Habib-Jiwan JL, Opperdoes FR, Quetin-Leclercq J.
J Nat Prod (2007) 70 : 1360 -1363
PubMed 17637068 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.22 7.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL265502 SURAMIN 3.0 1 7.39
CHEMBL169 URSOLIC ACID 2.0 1 5.66
CHEMBL252561 1 5.50
CHEMBL168 OLEANOLIC_ACID 1 5.19
CHEMBL252366 SARINGOSTEROL 1 5.11
CHEMBL23236 BETULIN 1 5.05
CHEMBL400074 ERYTHRODIOL 1 4.92
CHEMBL399873 UVAOL 1 4.56
CHEMBL269277 BETULINIC ACID 1.0 1 4.49
CHEMBL289191 LUPEOL 1 4.34
CHEMBL252364 STIGMASTANOL 1 -
CHEMBL455098 beta-AMYRIN 1 -
CHEMBL455357 1 -
CHEMBL221542 BETA-SITOSTEROL 1 -
CHEMBL400247 STIGMASTEROL 1 -
CHEMBL252365 CLEROSTEROL 1 -
CHEMBL107 COLCHICINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL265502 SURAMIN IC50 = 41.0 nM 7.39
CHEMBL169 URSOLIC ACID IC50 = 2200.0 nM 5.66
CHEMBL252561 IC50 = 3200.0 nM 5.50
CHEMBL168 OLEANOLIC_ACID IC50 = 6400.0 nM 5.19
CHEMBL252366 SARINGOSTEROL IC50 = 7800.0 nM 5.11
CHEMBL23236 BETULIN IC50 = 8900.0 nM 5.05
CHEMBL400074 ERYTHRODIOL IC50 = 12000.0 nM 4.92
CHEMBL399873 UVAOL IC50 = 27800.0 nM 4.56
CHEMBL269277 BETULINIC ACID IC50 = 32600.0 nM 4.49
CHEMBL289191 LUPEOL IC50 = 45300.0 nM 4.34
CHEMBL252364 STIGMASTANOL IC50 > 240000.0 nM -
CHEMBL455098 beta-AMYRIN IC50 = 126900.0 nM -
CHEMBL455357 IC50 = 114500.0 nM -
CHEMBL221542 BETA-SITOSTEROL IC50 > 241100.0 nM -
CHEMBL400247 STIGMASTEROL IC50 = 134600.0 nM -
CHEMBL252365 CLEROSTEROL IC50 = 129800.0 nM -
CHEMBL107 COLCHICINE IC50 - -