Compound Detail
CHEMBL252366
SARINGOSTEROL Enter ChEMBL ID:
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C=CC(O)(CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C
Basic Information
| ChEMBL ID | CHEMBL252366 |
| Name | SARINGOSTEROL |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OPGVEUGCNGNPSX-SVSQYMGHSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
428.7
MW (Da)
6.92
ALogP
2
HBA
2
HBD
40.5
PSA (Ų)
0.45
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 5.11 | 5.11 | 7800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei brucei | IC50 | = | 7800.0 | nM | 5.11 | Antitrypanosomal activity against Trypanosoma brucei brucei bloodstream trypomas... | 17637068 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17637068 | 10.1021/np070038q | Trypanosoma brucei brucei | 1 |
| 17637068 | 10.1021/np070038q | J774 | 1 |
| 17637068 | 10.1021/np070038q | Unchecked | 1 |
| 11720535 | 10.1021/np010101q | Mycobacterium tuberculosis | 1 |
| 11720535 | 10.1021/np010101q | Vero | 1 |
Data from ChEMBL 36 via Core Engine