Assay Detail
Functional
CHEMBL926528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against AR-negative human DU145 cells by trypan blue exclusion assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of (E)-styrylbenzylsulfones as novel anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.83 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1627071 | — | — | 1 | 8.60 |
| CHEMBL253178 | — | — | 1 | 8.52 |
| CHEMBL254849 | — | — | 1 | 7.60 |
| CHEMBL254640 | — | — | 1 | 6.60 |
| CHEMBL252971 | — | — | 1 | 6.30 |
| CHEMBL399125 | — | — | 1 | 6.30 |
| CHEMBL400686 | — | — | 1 | 5.90 |
| CHEMBL254631 | — | — | 1 | 5.70 |
| CHEMBL254004 | — | — | 1 | 5.60 |
| CHEMBL254630 | — | — | 1 | 5.46 |
| CHEMBL253177 | — | — | 1 | 5.40 |
| CHEMBL442433 | — | — | 1 | 5.30 |
| CHEMBL254427 | — | — | 1 | 5.12 |
| CHEMBL253599 | — | — | 1 | 5.12 |
| CHEMBL398534 | — | — | 1 | 5.12 |
| CHEMBL253600 | — | — | 1 | 5.12 |
| CHEMBL401361 | — | — | 1 | 5.00 |
| CHEMBL436632 | — | — | 1 | 5.00 |
| CHEMBL254224 | — | — | 1 | 4.92 |
| CHEMBL253382 | — | — | 1 | 4.90 |
| CHEMBL253383 | — | — | 1 | 4.82 |
| CHEMBL403573 | — | — | 1 | - |
| CHEMBL398340 | — | — | 1 | - |
| CHEMBL439229 | — | — | 1 | - |
| CHEMBL254638 | — | — | 1 | - |
| CHEMBL254639 | — | — | 1 | - |
| CHEMBL401845 | — | — | 1 | - |
| CHEMBL254641 | — | — | 1 | - |
| CHEMBL403576 | — | — | 1 | - |
| CHEMBL254847 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1627071 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL253178 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL254849 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL254640 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL252971 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL399125 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL400686 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL254631 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL254004 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL254630 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL253177 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL442433 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL253600 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL398534 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL253599 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL254427 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL436632 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL401361 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL254224 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL253382 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL253383 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL439407 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL252970 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL403792 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL254848 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL403791 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL254847 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL403576 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL254641 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL401845 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL254639 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL254638 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL439229 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL398340 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL403573 | — | IC50 | > | 20000.0 | nM | - |