Assay Detail
Binding
CHEMBL928078
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Activity at rat cloned iGluR4 expressed in human HEK293 cells by calcium imaging assay
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.65 | 4.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 2 | 4.78 |
| CHEMBL260328 | — | — | 2 | 4.53 |
| CHEMBL260327 | — | — | 1 | - |
| CHEMBL30285 | IBOTENIC ACID | — | 1 | - |
| CHEMBL260122 | — | — | 1 | - |
| CHEMBL406621 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 16595.87 | nM | 4.78 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL260328 | — | EC50 | = | 29512.09 | nM | 4.53 |
| CHEMBL260328 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL260327 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL30285 | IBOTENIC ACID | EC50 | > | 1000000.0 | nM | - |
| CHEMBL260122 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL406621 | — | EC50 | > | 1000000.0 | nM | - |