Assay Detail
Binding
CHEMBL928328
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Inhibition of PDE4A
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a potent new chemotype for the selective inhibition of PDE4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.35 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL251785 | — | — | 1 | 7.62 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL251785 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 84.0 | nM | 7.08 |