Assay Detail
Binding
CHEMBL928515
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IGF1R
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-(1H-Imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.75 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256072 | — | — | 1 | 7.42 |
| CHEMBL256495 | — | — | 1 | 7.18 |
| CHEMBL256908 | — | — | 1 | 7.17 |
| CHEMBL256074 | — | — | 1 | 7.12 |
| CHEMBL442450 | — | — | 1 | 7.09 |
| CHEMBL257114 | — | — | 1 | 7.09 |
| CHEMBL256073 | — | — | 1 | 7.08 |
| CHEMBL256909 | — | — | 1 | 7.04 |
| CHEMBL257326 | — | — | 1 | 7.02 |
| CHEMBL257115 | — | — | 1 | 7.02 |
| CHEMBL401930 | — | — | 1 | 7.00 |
| CHEMBL256703 | — | — | 1 | 6.96 |
| CHEMBL257325 | — | — | 1 | 6.96 |
| CHEMBL401766 | — | — | 1 | 6.92 |
| CHEMBL256702 | — | — | 1 | 6.80 |
| CHEMBL403015 | — | — | 1 | 6.76 |
| CHEMBL256275 | — | — | 1 | 6.72 |
| CHEMBL256701 | — | — | 1 | 6.61 |
| CHEMBL257324 | — | — | 1 | 6.57 |
| CHEMBL256494 | — | — | 1 | 6.54 |
| CHEMBL401767 | — | — | 1 | 6.54 |
| CHEMBL256910 | — | — | 1 | 6.48 |
| CHEMBL404307 | — | — | 1 | 6.44 |
| CHEMBL256277 | — | — | 1 | 6.44 |
| CHEMBL257116 | — | — | 1 | 6.33 |
| CHEMBL256276 | — | — | 1 | 6.32 |
| CHEMBL402623 | — | — | 1 | 6.29 |
| CHEMBL403218 | — | — | 1 | 6.26 |
| CHEMBL402625 | — | — | 1 | 6.20 |
| CHEMBL404308 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256072 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL256495 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL256908 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL256074 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL442450 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL257114 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL256073 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL256909 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL257326 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL257115 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL401930 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL256703 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL257325 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL401766 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL256702 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL403015 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL256275 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL256701 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL257324 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL256494 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL401767 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL256910 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL404307 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL256277 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL257116 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL256276 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL402623 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL403218 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL402625 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL404308 | — | IC50 | = | 680.0 | nM | 6.17 |