Compound Detail
CHEMBL402625
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL402625 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WMYLLNRTTFMLHY-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
468.0
MW (Da)
3.33
ALogP
7
HBA
3
HBD
103.9
PSA (Ų)
0.40
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 6.2 | 6.155 | 630.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 630.0 | nM | 6.2 | Inhibition of IGF1R | 18258427 |
| Insulin-like growth factor 1 receptor | IC50 | = | 777.0 | nM | 6.11 | Inhibition of IGF1R expressed in SAL cells | 18258427 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18258427 | 10.1016/j.bmcl.2008.01.049 | Insulin-like growth factor 1 receptor | 2 |
Data from ChEMBL 36 via Core Engine