Assay Detail
Binding
CHEMBL928516
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Inhibition of IGF1R expressed in SAL cells
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | SAL |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-(1H-Imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.32 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401930 | — | — | 1 | 6.96 |
| CHEMBL257114 | — | — | 1 | 6.84 |
| CHEMBL257325 | — | — | 1 | 6.71 |
| CHEMBL256495 | — | — | 1 | 6.58 |
| CHEMBL403015 | — | — | 1 | 6.55 |
| CHEMBL257326 | — | — | 1 | 6.54 |
| CHEMBL256702 | — | — | 1 | 6.51 |
| CHEMBL256072 | — | — | 1 | 6.47 |
| CHEMBL256074 | — | — | 1 | 6.46 |
| CHEMBL256277 | — | — | 1 | 6.44 |
| CHEMBL401766 | — | — | 1 | 6.42 |
| CHEMBL256703 | — | — | 1 | 6.40 |
| CHEMBL401767 | — | — | 1 | 6.38 |
| CHEMBL442450 | — | — | 1 | 6.35 |
| CHEMBL256073 | — | — | 1 | 6.33 |
| CHEMBL256275 | — | — | 1 | 6.28 |
| CHEMBL256908 | — | — | 1 | 6.28 |
| CHEMBL257324 | — | — | 1 | 6.27 |
| CHEMBL256276 | — | — | 1 | 6.23 |
| CHEMBL256494 | — | — | 1 | 6.21 |
| CHEMBL256910 | — | — | 1 | 6.21 |
| CHEMBL257115 | — | — | 1 | 6.16 |
| CHEMBL402623 | — | — | 1 | 6.16 |
| CHEMBL256909 | — | — | 1 | 6.15 |
| CHEMBL402625 | — | — | 1 | 6.11 |
| CHEMBL257116 | — | — | 1 | 6.10 |
| CHEMBL404308 | — | — | 1 | 6.09 |
| CHEMBL404307 | — | — | 1 | 5.94 |
| CHEMBL403218 | — | — | 1 | 5.82 |
| CHEMBL256701 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401930 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL257114 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL257325 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL256495 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL403015 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL257326 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL256702 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL256072 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL256074 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL256277 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL401766 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL256703 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL401767 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL442450 | — | IC50 | = | 451.0 | nM | 6.35 |
| CHEMBL256073 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL256275 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL256908 | — | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL257324 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL256276 | — | IC50 | = | 583.0 | nM | 6.23 |
| CHEMBL256494 | — | IC50 | = | 622.0 | nM | 6.21 |
| CHEMBL256910 | — | IC50 | = | 613.0 | nM | 6.21 |
| CHEMBL257115 | — | IC50 | = | 697.0 | nM | 6.16 |
| CHEMBL402623 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL256909 | — | IC50 | = | 711.0 | nM | 6.15 |
| CHEMBL402625 | — | IC50 | = | 777.0 | nM | 6.11 |
| CHEMBL257116 | — | IC50 | = | 796.0 | nM | 6.10 |
| CHEMBL404308 | — | IC50 | = | 821.0 | nM | 6.09 |
| CHEMBL404307 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL403218 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL256701 | — | IC50 | = | 2034.0 | nM | 5.69 |