Assay Detail
Binding
CHEMBL929127
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Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small-molecule activators of RNase L with broad-spectrum antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.76 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404038 | — | — | 1 | 9.30 |
| CHEMBL259804 | — | — | 1 | 4.66 |
| CHEMBL259633 | — | — | 1 | 4.66 |
| CHEMBL259819 | — | — | 1 | 4.58 |
| CHEMBL265438 | — | — | 1 | 4.58 |
| CHEMBL261864 | — | — | 1 | 4.32 |
| CHEMBL410485 | — | — | 1 | 4.31 |
| CHEMBL411931 | — | — | 1 | 4.31 |
| CHEMBL260229 | — | — | 1 | 4.30 |
| CHEMBL265469 | — | — | 1 | 4.10 |
| CHEMBL408340 | — | — | 1 | 4.05 |
| CHEMBL406556 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404038 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL259804 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL259633 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL259819 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL265438 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL261864 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL410485 | — | EC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL411931 | — | EC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL260229 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL265469 | — | EC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL408340 | — | EC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL406556 | — | EC50 | = | 99000.0 | nM | 4.00 |