Compound Detail
CHEMBL259633
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Basic Information
| ChEMBL ID | CHEMBL259633 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YEBWEMIJOWUBEM-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
298.4
MW (Da)
3.24
ALogP
4
HBA
2
HBD
66.0
PSA (Ų)
0.72
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.66
Kd 1 meas. best 4.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 2-5A-dependent ribonuclease CHEMBL3575 | Kd | 4.92 | 4.92 | 12000.0 | 1 |
| 2-5A-dependent ribonuclease CHEMBL3575 | EC50 | 4.66 | 4.66 | 22000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 2-5A-dependent ribonuclease | Kd | = | 12000.0 | nM | 4.92 | Displacement of 5'-phosphorylated, 2',5'-oligoadenylate from human recombinant R... | 17535916 |
| 2-5A-dependent ribonuclease | EC50 | = | 22000.0 | nM | 4.66 | Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe | 17535916 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17535916 | 10.1073/pnas.0700590104 | 2-5A-dependent ribonuclease | 6 |
| 17535916 | 10.1073/pnas.0700590104 | Human respirovirus 3 | 3 |
| 17535916 | 10.1073/pnas.0700590104 | Encephalomyocarditis virus | 2 |
| 17535916 | 10.1073/pnas.0700590104 | NON-PROTEIN TARGET | 2 |
| 17535916 | 10.1073/pnas.0700590104 | ADMET | 1 |
| 17535916 | 10.1073/pnas.0700590104 | Respirovirus muris | 1 |
Data from ChEMBL 36 via Core Engine