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Assay Detail

CHEMBL929236

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma brucei (CHEMBL612849)
Type ORGANISM
Organism Trypanosoma brucei

Publication

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.
Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK.
Bioorg Med Chem Lett (2008) 18 : 2883 -2885
PubMed 18420405 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 5.58 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL261438 1 5.96
CHEMBL406601 1 5.89
CHEMBL261657 THIOSEMICARBAZONE STANDARD 1 5.89
CHEMBL407264 1 5.82
CHEMBL410086 1 5.70
CHEMBL404938 1 5.60
CHEMBL258588 1 5.43
CHEMBL261218 1 5.22
CHEMBL260921 1 5.16
CHEMBL259379 1 5.16
CHEMBL429858 1 -
CHEMBL402465 1 -
CHEMBL261307 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL261438 EC50 = 1100.0 nM 5.96
CHEMBL406601 EC50 = 1300.0 nM 5.89
CHEMBL261657 THIOSEMICARBAZONE STANDARD EC50 = 1300.0 nM 5.89
CHEMBL407264 EC50 = 1500.0 nM 5.82
CHEMBL410086 EC50 = 2000.0 nM 5.70
CHEMBL404938 EC50 = 2500.0 nM 5.60
CHEMBL258588 EC50 = 3700.0 nM 5.43
CHEMBL261218 EC50 = 6000.0 nM 5.22
CHEMBL260921 EC50 = 7000.0 nM 5.16
CHEMBL259379 EC50 = 7000.0 nM 5.16
CHEMBL429858 EC50 > 10000.0 nM -
CHEMBL402465 EC50 > 10000.0 nM -
CHEMBL261307 EC50 > 10000.0 nM -