Assay Detail
ADMET
CHEMBL929419
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Inhibition of CYP3A4
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.07 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409442 | — | — | 1 | 5.19 |
| CHEMBL261592 | — | — | 1 | 4.94 |
| CHEMBL258694 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409442 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL261592 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL258694 | — | IC50 | > | 40000.0 | nM | - |