Assay Detail
Functional
CHEMBL930321
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Inhibition of TNF-alpha-induced necroptosis in FADD-deficient human Jurkat T cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.11 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195008 | NECROSTATIN | — | 1 | 7.30 |
| CHEMBL259796 | — | — | 1 | 7.04 |
| CHEMBL249199 | — | — | 1 | 6.55 |
| CHEMBL406005 | — | — | 1 | 6.47 |
| CHEMBL403825 | — | — | 1 | 6.36 |
| CHEMBL405799 | — | — | 1 | 6.28 |
| CHEMBL256716 | — | — | 1 | 6.13 |
| CHEMBL256342 | — | — | 1 | 6.05 |
| CHEMBL259798 | — | — | 1 | 5.85 |
| CHEMBL405418 | — | — | 1 | 5.72 |
| CHEMBL407892 | — | — | 1 | 5.68 |
| CHEMBL259695 | — | — | 1 | 5.62 |
| CHEMBL404039 | — | — | 1 | 5.31 |
| CHEMBL402102 | — | — | 1 | 5.11 |
| CHEMBL256512 | — | — | 1 | - |
| CHEMBL428428 | — | — | 1 | - |
| CHEMBL261302 | — | — | 1 | - |
| CHEMBL256343 | — | — | 1 | - |
| CHEMBL406346 | — | — | 1 | - |
| CHEMBL444021 | — | — | 1 | - |
| CHEMBL259696 | — | — | 1 | - |
| CHEMBL265207 | — | — | 1 | - |
| CHEMBL259595 | — | — | 1 | - |
| CHEMBL405748 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195008 | NECROSTATIN | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL259796 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL249199 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL406005 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL403825 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL405799 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL256716 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL256342 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL259798 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL405418 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL407892 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL259695 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL404039 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL402102 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL256512 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL428428 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL261302 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL256343 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL406346 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL444021 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL259696 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL265207 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL259595 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL405748 | — | EC50 | > | 20000.0 | nM | - |