Assay Detail
Binding
CHEMBL930537
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Displacement of [3H]neomonapride from dopamine D2 receptor in rat striatum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.91 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 9.05 |
| CHEMBL53294 | — | — | 1 | 8.89 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.72 |
| CHEMBL53445 | — | — | 1 | 8.46 |
| CHEMBL405369 | — | — | 1 | 7.55 |
| CHEMBL27559 | — | — | 1 | 7.54 |
| CHEMBL405345 | — | — | 1 | 7.36 |
| CHEMBL119455 | — | — | 1 | 6.97 |
| CHEMBL270426 | — | — | 1 | 6.63 |
| CHEMBL406269 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL53294 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL53 | APOMORPHINE | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL53445 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL405369 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL27559 | — | Ki | = | 28.5 | nM | 7.54 |
| CHEMBL405345 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL119455 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL270426 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL406269 | — | Ki | > | 10000.0 | nM | - |