Assay Detail
Binding
CHEMBL931028
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Inhibition of pig liver carboxylesterase after 5 mins
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.38 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270374 | — | — | 1 | 8.66 |
| CHEMBL269931 | — | — | 1 | 8.26 |
| CHEMBL89506 | — | — | 1 | 8.25 |
| CHEMBL440542 | — | — | 1 | 8.12 |
| CHEMBL270375 | — | — | 1 | 7.92 |
| CHEMBL273138 | — | — | 1 | 7.92 |
| CHEMBL402615 | — | — | 1 | 7.70 |
| CHEMBL86668 | — | — | 1 | 7.60 |
| CHEMBL257071 | — | — | 1 | 7.43 |
| CHEMBL272075 | — | — | 1 | 7.20 |
| CHEMBL270373 | — | — | 1 | 6.70 |
| CHEMBL155396 | — | — | 1 | 6.55 |
| CHEMBL155621 | — | — | 1 | 6.33 |
| CHEMBL273139 | — | — | 1 | 6.08 |
| CHEMBL403288 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270374 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL269931 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL89506 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL440542 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL270375 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL273138 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL402615 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL86668 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL257071 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL272075 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL270373 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL155396 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL155621 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL273139 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL403288 | — | IC50 | = | 970.0 | nM | 6.01 |