Assay Detail
Functional
CHEMBL931447
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at muscarinic M3 receptor in carbachol-stimulated guinea pig trachea
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL5498) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 10 | - | - |
| Kd | 2 | 8.20 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409151 | — | — | 1 | 8.20 |
| CHEMBL264676 | — | — | 1 | 8.20 |
| CHEMBL381623 | — | — | 1 | - |
| CHEMBL3545181 | TIOTROPIUM BROMIDE | 4.0 | 1 | - |
| CHEMBL1908368 | — | — | 1 | - |
| CHEMBL410061 | — | — | 1 | - |
| CHEMBL258959 | — | — | 1 | - |
| CHEMBL411514 | — | — | 1 | - |
| CHEMBL260228 | — | — | 1 | - |
| CHEMBL264414 | — | — | 1 | - |
| CHEMBL371734 | — | — | 1 | - |
| CHEMBL428962 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409151 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL264676 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL381623 | — | Activity | - | — | - | |
| CHEMBL3545181 | TIOTROPIUM BROMIDE | Activity | - | — | - | |
| CHEMBL1908368 | — | Activity | - | — | - | |
| CHEMBL410061 | — | Activity | - | — | - | |
| CHEMBL258959 | — | Activity | - | — | - | |
| CHEMBL411514 | — | Activity | - | — | - | |
| CHEMBL260228 | — | Activity | - | — | - | |
| CHEMBL264414 | — | Activity | - | — | - | |
| CHEMBL371734 | — | Activity | - | — | - | |
| CHEMBL428962 | — | Activity | - | — | - |