Assay Detail

CHEMBL931637

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Functional

Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay

ChEMBL ↗

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Target

P388 (CHEMBL389) ↗

Open DB target context

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P388 (CHEMBL389) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target P388

CHEMBL389

Anchored from Assay target.

Protein identity P388

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	P388
Confidence	1 — Organism
Curated By	Autocuration

Target

P388 (CHEMBL389) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines.

James DA, Koya K, Li H, Liang G, Xia Z, Ying W, Wu Y, Sun L.
Bioorg Med Chem Lett (2008) 18 : 1784 -1787
PubMed 18308566 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.00	8.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL271068	ROSABULIN	2.0	1	8.00
CHEMBL428647	PACLITAXEL	4.0	1	8.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL271068	ROSABULIN	IC50	=	10.0	nM	8.00
CHEMBL428647	PACLITAXEL	IC50	=	10.0	nM	8.00