Assay Detail

CHEMBL931638

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Functional

Cytotoxicity against human DU145 cells after 72 hrs by MTT assay

ChEMBL ↗

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Target

DU-145 (CHEMBL613508) ↗

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Primary target DU-145

CHEMBL613508

Anchored from Assay target.

Protein identity DU-145

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	DU-145
Confidence	1 — Organism
Curated By	Autocuration

Target

DU-145 (CHEMBL613508) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines.

James DA, Koya K, Li H, Liang G, Xia Z, Ying W, Wu Y, Sun L.
Bioorg Med Chem Lett (2008) 18 : 1784 -1787
PubMed 18308566 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.80	8.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL428647	PACLITAXEL	4.0	1	8.30
CHEMBL271068	ROSABULIN	2.0	1	7.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL428647	PACLITAXEL	IC50	=	5.0	nM	8.30
CHEMBL271068	ROSABULIN	IC50	=	50.0	nM	7.30