Assay Detail
Functional
CHEMBL931760
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Induction of apoptosis in human T47D cells assessed as caspase activation by HTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: modifications of the 2- and 3-positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.14 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399124 | — | — | 1 | 8.70 |
| CHEMBL229110 | — | — | 1 | 8.30 |
| CHEMBL196832 | — | — | 1 | 7.72 |
| CHEMBL272709 | — | — | 1 | 7.54 |
| CHEMBL272930 | — | — | 1 | 7.33 |
| CHEMBL402799 | — | — | 1 | 7.19 |
| CHEMBL258344 | — | — | 1 | 7.17 |
| CHEMBL273137 | — | — | 1 | 7.16 |
| CHEMBL403690 | — | — | 1 | 6.60 |
| CHEMBL228826 | — | — | 1 | 6.57 |
| CHEMBL404896 | — | — | 1 | 5.85 |
| CHEMBL256241 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399124 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL229110 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL196832 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL272709 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL272930 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL402799 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL258344 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL273137 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL403690 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL228826 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL404896 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL256241 | — | EC50 | = | 3200.0 | nM | 5.50 |