Assay Detail
Functional
CHEMBL931830
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Antitumor activity against human LOVO cells after 4 hrs by MTT assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New homocamptothecins: synthesis, antitumor activity, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 7.04 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272055 | — | — | 1 | 9.40 |
| CHEMBL272724 | — | — | 1 | 9.10 |
| CHEMBL429417 | — | — | 1 | 8.70 |
| CHEMBL427894 | — | — | 1 | 8.52 |
| CHEMBL404149 | — | — | 1 | 8.15 |
| CHEMBL255187 | — | — | 1 | 7.96 |
| CHEMBL272726 | — | — | 1 | 7.85 |
| CHEMBL271465 | — | — | 1 | 7.85 |
| CHEMBL404712 | — | — | 1 | 7.82 |
| CHEMBL255120 | — | — | 1 | 7.75 |
| CHEMBL255217 | — | — | 1 | 7.70 |
| CHEMBL401635 | — | — | 1 | 7.68 |
| CHEMBL271466 | — | — | 1 | 7.64 |
| CHEMBL404838 | — | — | 1 | 7.62 |
| CHEMBL270425 | — | — | 1 | 7.50 |
| CHEMBL401755 | — | — | 1 | 7.46 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.44 |
| CHEMBL258121 | — | — | 1 | 7.40 |
| CHEMBL404573 | — | — | 1 | 7.30 |
| CHEMBL411872 | — | — | 1 | 7.22 |
| CHEMBL255188 | — | — | 1 | 6.90 |
| CHEMBL272056 | — | — | 1 | 6.43 |
| CHEMBL429573 | — | — | 1 | 6.42 |
| CHEMBL404302 | — | — | 1 | 6.27 |
| CHEMBL1202382 | — | — | 1 | 5.45 |
| CHEMBL255425 | — | — | 1 | 5.29 |
| CHEMBL271875 | — | — | 1 | 5.15 |
| CHEMBL269993 | — | — | 1 | 5.10 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 5.04 |
| CHEMBL255366 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272055 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL272724 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL429417 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL427894 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL404149 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL255187 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL272726 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL271465 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL404712 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL255120 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL255217 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL401635 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL271466 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL404838 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL270425 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL401755 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL258121 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL404573 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL411872 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL255188 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL272056 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL429573 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL404302 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL1202382 | — | IC50 | = | 3543.0 | nM | 5.45 |
| CHEMBL255425 | — | IC50 | = | 5192.0 | nM | 5.29 |
| CHEMBL271875 | — | IC50 | = | 7080.0 | nM | 5.15 |
| CHEMBL269993 | — | IC50 | = | 7912.0 | nM | 5.10 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 9015.0 | nM | 5.04 |
| CHEMBL255366 | — | IC50 | = | 9039.0 | nM | 5.04 |
| CHEMBL255563 | — | IC50 | = | 9318.0 | nM | 5.03 |
| CHEMBL404617 | — | IC50 | = | 10729.0 | nM | 4.97 |
| CHEMBL271716 | — | IC50 | > | 19730.0 | nM | - |
| CHEMBL411639 | — | IC50 | > | 20720.0 | nM | - |
| CHEMBL270211 | — | IC50 | > | 21340.0 | nM | - |
| CHEMBL255332 | — | IC50 | < | 0.2 | nM | - |
| CHEMBL255365 | — | IC50 | > | 21160.0 | nM | - |
| CHEMBL271665 | — | IC50 | > | 20450.0 | nM | - |
| CHEMBL272982 | — | IC50 | > | 20720.0 | nM | - |
| CHEMBL271891 | — | IC50 | > | 20720.0 | nM | - |
| CHEMBL407463 | — | IC50 | < | 0.2 | nM | - |
| CHEMBL404403 | — | IC50 | > | 19510.0 | nM | - |
| CHEMBL403974 | — | IC50 | > | 19510.0 | nM | - |
| CHEMBL403643 | — | IC50 | > | 20720.0 | nM | - |
| CHEMBL270449 | — | IC50 | > | 21160.0 | nM | - |
| CHEMBL401634 | — | IC50 | > | 19110.0 | nM | - |
| CHEMBL273133 | — | IC50 | > | 19510.0 | nM | - |