Assay Detail
Binding
CHEMBL932042
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Inhibition of human recombinant p38alpha
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.93 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270657 | — | — | 1 | 8.64 |
| CHEMBL442972 | — | — | 1 | 8.60 |
| CHEMBL409698 | — | — | 1 | 8.49 |
| CHEMBL272108 | — | — | 1 | 8.46 |
| CHEMBL274201 | — | — | 1 | 8.44 |
| CHEMBL429422 | — | — | 1 | 8.43 |
| CHEMBL271505 | — | — | 1 | 8.41 |
| CHEMBL272731 | — | — | 1 | 8.41 |
| CHEMBL192848 | — | — | 1 | 8.38 |
| CHEMBL404377 | — | — | 1 | 8.36 |
| CHEMBL272989 | — | — | 1 | 8.35 |
| CHEMBL364572 | — | — | 1 | 8.31 |
| CHEMBL402188 | — | — | 1 | 8.29 |
| CHEMBL402219 | — | — | 1 | 8.22 |
| CHEMBL437030 | — | — | 1 | 8.21 |
| CHEMBL403294 | — | — | 1 | 8.19 |
| CHEMBL402399 | — | — | 1 | 8.17 |
| CHEMBL271059 | — | — | 1 | 8.15 |
| CHEMBL411291 | — | — | 1 | 8.15 |
| CHEMBL404118 | — | — | 1 | 8.14 |
| CHEMBL270002 | — | — | 1 | 8.07 |
| CHEMBL270842 | — | — | 1 | 8.06 |
| CHEMBL444636 | — | — | 1 | 8.00 |
| CHEMBL256684 | — | — | 1 | 7.95 |
| CHEMBL272142 | — | — | 1 | 7.84 |
| CHEMBL192889 | — | — | 1 | 7.82 |
| CHEMBL404645 | — | — | 1 | 7.79 |
| CHEMBL258150 | — | — | 1 | 7.69 |
| CHEMBL271443 | — | — | 1 | 7.58 |
| CHEMBL403737 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270657 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL442972 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL409698 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL272108 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL274201 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL429422 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL271505 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL272731 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL192848 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL404377 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL272989 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL364572 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL402188 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL402219 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL437030 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL403294 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL402399 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL411291 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL271059 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL404118 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL270002 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL270842 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL444636 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL256684 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL272142 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL192889 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL404645 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL258150 | — | IC50 | = | 20.4 | nM | 7.69 |
| CHEMBL271443 | — | IC50 | = | 26.1 | nM | 7.58 |
| CHEMBL403737 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL403851 | — | IC50 | = | 56.4 | nM | 7.25 |
| CHEMBL272535 | — | IC50 | = | 88.4 | nM | 7.05 |
| CHEMBL272735 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL402617 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL404547 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL272537 | — | IC50 | = | 2489.0 | nM | 5.60 |