Compound Detail
CHEMBL271505
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CC(C)Cn1cnc2ccc(-c3[nH]c(C(C)(C)C)nc3-c3ccc(F)cc3F)nc21.CS(=O)(=O)O
Basic Information
| ChEMBL ID | CHEMBL271505 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PBGFFQAZYPZGAM-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1182892 |
| Active Moiety | CHEMBL1182892 |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
409.5
MW (Da)
5.72
ALogP
4
HBA
1
HBD
59.4
PSA (Ų)
0.47
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 8.41 | 8.41 | 3.9 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL2336 | IC50 | 7.38 | 7.38 | 41.8 | 1 |
| Macrophage CHEMBL612578 | IC50 | 7.31 | 7.31 | 49.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 3.9 | nM | 8.41 | Inhibition of human recombinant p38alpha | 18039577 |
| Mitogen-activated protein kinase 14 | IC50 | = | 41.8 | nM | 7.38 | Inhibition of mouse p38alpha in anisomycin-stimulated RAW 264.7 cells by ELISA | 18039577 |
| Macrophage | IC50 | = | 49.2 | nM | 7.31 | Inhibition of LPS-stimulated TNFalpha production in mouse peritoneal macrophages | 18039577 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18039577 | 10.1016/j.bmcl.2007.10.106 | Mitogen-activated protein kinase 14 | 2 |
| 18039577 | 10.1016/j.bmcl.2007.10.106 | Macrophage | 1 |
Data from ChEMBL 36 via Core Engine