Assay Detail
Binding
CHEMBL932044
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Inhibition of mouse p38alpha in anisomycin-stimulated RAW 264.7 cells by ELISA
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.11 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270657 | — | — | 1 | 7.68 |
| CHEMBL274201 | — | — | 1 | 7.64 |
| CHEMBL404377 | — | — | 1 | 7.58 |
| CHEMBL402399 | — | — | 1 | 7.56 |
| CHEMBL272731 | — | — | 1 | 7.51 |
| CHEMBL411291 | — | — | 1 | 7.46 |
| CHEMBL442972 | — | — | 1 | 7.46 |
| CHEMBL409698 | — | — | 1 | 7.41 |
| CHEMBL192889 | — | — | 1 | 7.41 |
| CHEMBL271505 | — | — | 1 | 7.38 |
| CHEMBL364572 | — | — | 1 | 7.34 |
| CHEMBL270842 | — | — | 1 | 7.22 |
| CHEMBL437030 | — | — | 1 | 7.21 |
| CHEMBL429422 | — | — | 1 | 7.19 |
| CHEMBL402188 | — | — | 1 | 7.18 |
| CHEMBL272989 | — | — | 1 | 7.16 |
| CHEMBL272142 | — | — | 1 | 7.13 |
| CHEMBL444636 | — | — | 1 | 7.11 |
| CHEMBL402219 | — | — | 1 | 6.90 |
| CHEMBL192848 | — | — | 1 | 6.71 |
| CHEMBL271059 | — | — | 1 | 6.65 |
| CHEMBL271443 | — | — | 1 | 6.55 |
| CHEMBL272108 | — | — | 1 | 6.53 |
| CHEMBL403737 | — | — | 1 | 6.42 |
| CHEMBL270002 | — | — | 1 | 6.40 |
| CHEMBL272535 | — | — | 1 | 6.12 |
| CHEMBL402617 | — | — | 1 | - |
| CHEMBL404118 | — | — | 1 | - |
| CHEMBL258150 | — | — | 1 | - |
| CHEMBL403294 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270657 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL274201 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL404377 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL402399 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL272731 | — | IC50 | = | 31.2 | nM | 7.51 |
| CHEMBL411291 | — | IC50 | = | 34.3 | nM | 7.46 |
| CHEMBL442972 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL409698 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL192889 | — | IC50 | = | 38.9 | nM | 7.41 |
| CHEMBL271505 | — | IC50 | = | 41.8 | nM | 7.38 |
| CHEMBL364572 | — | IC50 | = | 45.7 | nM | 7.34 |
| CHEMBL270842 | — | IC50 | = | 59.7 | nM | 7.22 |
| CHEMBL437030 | — | IC50 | = | 62.3 | nM | 7.21 |
| CHEMBL429422 | — | IC50 | = | 64.7 | nM | 7.19 |
| CHEMBL402188 | — | IC50 | = | 66.4 | nM | 7.18 |
| CHEMBL272989 | — | IC50 | = | 69.7 | nM | 7.16 |
| CHEMBL272142 | — | IC50 | = | 74.5 | nM | 7.13 |
| CHEMBL444636 | — | IC50 | = | 78.3 | nM | 7.11 |
| CHEMBL402219 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL192848 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL271059 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL271443 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL272108 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL403737 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL270002 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL272535 | — | IC50 | = | 766.0 | nM | 6.12 |
| CHEMBL272537 | — | IC50 | - | — | - | |
| CHEMBL272735 | — | IC50 | - | — | - | |
| CHEMBL403851 | — | IC50 | - | — | - | |
| CHEMBL404645 | — | IC50 | - | — | - | |
| CHEMBL256684 | — | IC50 | - | — | - | |
| CHEMBL404547 | — | IC50 | - | — | - | |
| CHEMBL403294 | — | IC50 | - | — | - | |
| CHEMBL258150 | — | IC50 | - | — | - | |
| CHEMBL404118 | — | IC50 | - | — | - | |
| CHEMBL402617 | — | IC50 | - | — | - |