Assay Detail
Functional
CHEMBL932043
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-stimulated TNFalpha production in mouse peritoneal macrophages
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.53 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442972 | — | — | 1 | 8.89 |
| CHEMBL429422 | — | — | 1 | 8.77 |
| CHEMBL270002 | — | — | 1 | 8.72 |
| CHEMBL192889 | — | — | 1 | 8.59 |
| CHEMBL402219 | — | — | 1 | 8.46 |
| CHEMBL272108 | — | — | 1 | 8.43 |
| CHEMBL402399 | — | — | 1 | 8.28 |
| CHEMBL411291 | — | — | 1 | 8.28 |
| CHEMBL404377 | — | — | 1 | 8.21 |
| CHEMBL364572 | — | — | 1 | 7.99 |
| CHEMBL272142 | — | — | 1 | 7.95 |
| CHEMBL437030 | — | — | 1 | 7.85 |
| CHEMBL270657 | — | — | 1 | 7.62 |
| CHEMBL272989 | — | — | 1 | 7.57 |
| CHEMBL192848 | — | — | 1 | 7.50 |
| CHEMBL271443 | — | — | 1 | 7.48 |
| CHEMBL270842 | — | — | 1 | 7.33 |
| CHEMBL444636 | — | — | 1 | 7.32 |
| CHEMBL271505 | — | — | 1 | 7.31 |
| CHEMBL404645 | — | — | 1 | 7.29 |
| CHEMBL402188 | — | — | 1 | 7.26 |
| CHEMBL403737 | — | — | 1 | 7.15 |
| CHEMBL271059 | — | — | 1 | 6.99 |
| CHEMBL258150 | — | — | 1 | 6.73 |
| CHEMBL272537 | — | — | 1 | 6.63 |
| CHEMBL256684 | — | — | 1 | 6.47 |
| CHEMBL272535 | — | — | 1 | 6.38 |
| CHEMBL403851 | — | — | 1 | 6.31 |
| CHEMBL402617 | — | — | 1 | 6.28 |
| CHEMBL272735 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442972 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL429422 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL270002 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL192889 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL402219 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL272108 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL402399 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL411291 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL404377 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL364572 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL272142 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL437030 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL270657 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL272989 | — | IC50 | = | 26.7 | nM | 7.57 |
| CHEMBL192848 | — | IC50 | = | 31.8 | nM | 7.50 |
| CHEMBL271443 | — | IC50 | = | 33.1 | nM | 7.48 |
| CHEMBL270842 | — | IC50 | = | 46.5 | nM | 7.33 |
| CHEMBL444636 | — | IC50 | = | 47.5 | nM | 7.32 |
| CHEMBL271505 | — | IC50 | = | 49.2 | nM | 7.31 |
| CHEMBL404645 | — | IC50 | = | 51.9 | nM | 7.29 |
| CHEMBL402188 | — | IC50 | = | 54.5 | nM | 7.26 |
| CHEMBL403737 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL271059 | — | IC50 | = | 103.5 | nM | 6.99 |
| CHEMBL258150 | — | IC50 | = | 186.4 | nM | 6.73 |
| CHEMBL272537 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL256684 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL272535 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL403851 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL402617 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL272735 | — | IC50 | = | 1326.0 | nM | 5.88 |
| CHEMBL403294 | — | IC50 | < | 9.0 | nM | - |
| CHEMBL272731 | — | IC50 | < | 9.0 | nM | - |
| CHEMBL404547 | — | IC50 | - | — | - | |
| CHEMBL409698 | — | IC50 | < | 9.0 | nM | - |
| CHEMBL404118 | — | IC50 | < | 9.0 | nM | - |
| CHEMBL274201 | — | IC50 | < | 9.0 | nM | - |