Assay Detail
Binding
CHEMBL932202
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Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M1 receptor expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of a fluorescent muscarinic antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.01 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1382 | TOLTERODINE | 4.0 | 1 | 8.85 |
| CHEMBL271108 | — | — | 1 | 8.34 |
| CHEMBL257643 | — | — | 1 | 7.47 |
| CHEMBL257431 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1382 | TOLTERODINE | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL271108 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL257643 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL257431 | — | Ki | = | 44.0 | nM | 7.36 |