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Assay Detail

CHEMBL932637

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Functional
Growth inhibition of human PC3M cells by SRB assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PC-3M
Confidence 1 — Organism
Curated By Autocuration

Publication

Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.
Caldwell JJ, Davies TG, Donald A, McHardy T, Rowlands MG, Aherne GW, Hunter LK, Taylor K, Ruddle R, Raynaud FI, Verdonk M, Workman P, Garrett MD, Collins I.
J Med Chem (2008) 51 : 2147 -2157
PubMed 18345609 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.85 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL406863 1 6.00
CHEMBL260577 1 5.28
CHEMBL260358 1 5.24
CHEMBL405384 1 5.13
CHEMBL259998 1 5.10
CHEMBL263664 1 4.92
CHEMBL260000 1 4.82
CHEMBL260463 1 4.80
CHEMBL104264 1 4.75
CHEMBL409503 1 4.70
CHEMBL261034 1 4.64
CHEMBL264965 1 4.51
CHEMBL261249 1 4.50
CHEMBL265451 1 4.42
CHEMBL261247 1 4.42
CHEMBL259141 1 4.32
CHEMBL259999 1 -
CHEMBL407504 1 -
CHEMBL265193 1 -
CHEMBL261260 1 -
CHEMBL259356 1 -
CHEMBL264667 1 -
CHEMBL265194 1 -
CHEMBL264666 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL406863 IC50 = 1000.0 nM 6.00
CHEMBL260577 IC50 = 5300.0 nM 5.28
CHEMBL260358 IC50 = 5700.0 nM 5.24
CHEMBL405384 IC50 = 7400.0 nM 5.13
CHEMBL259998 IC50 = 8000.0 nM 5.10
CHEMBL263664 IC50 = 12000.0 nM 4.92
CHEMBL260000 IC50 = 15000.0 nM 4.82
CHEMBL260463 IC50 = 16000.0 nM 4.80
CHEMBL104264 IC50 = 18000.0 nM 4.75
CHEMBL409503 IC50 = 20000.0 nM 4.70
CHEMBL261034 IC50 = 23000.0 nM 4.64
CHEMBL264965 IC50 = 31000.0 nM 4.51
CHEMBL261249 IC50 = 32000.0 nM 4.50
CHEMBL265451 IC50 = 38000.0 nM 4.42
CHEMBL261247 IC50 = 38000.0 nM 4.42
CHEMBL259141 IC50 = 48000.0 nM 4.32
CHEMBL259999 IC50 > 50000.0 nM -
CHEMBL407504 IC50 > 50000.0 nM -
CHEMBL265193 IC50 > 50000.0 nM -
CHEMBL261260 IC50 > 50000.0 nM -
CHEMBL259356 IC50 > 50000.0 nM -
CHEMBL264667 IC50 - -
CHEMBL265194 IC50 - -
CHEMBL264666 IC50 - -