Assay Detail
Functional
CHEMBL932782
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4
35
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and trypanocidal activity of new aminoadamantane derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.05 | 7.05 |
| IC90 | 16 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429426 | — | — | 2 | 7.05 |
| CHEMBL270339 | — | — | 2 | 6.39 |
| CHEMBL270260 | — | — | 2 | 6.38 |
| CHEMBL271608 | — | — | 2 | 6.33 |
| CHEMBL261602 | — | — | 2 | 6.32 |
| CHEMBL270540 | — | — | 2 | 6.23 |
| CHEMBL261601 | — | — | 2 | 6.10 |
| CHEMBL273129 | — | — | 2 | 6.08 |
| CHEMBL273131 | — | — | 2 | 6.04 |
| CHEMBL270541 | — | — | 2 | 5.96 |
| CHEMBL270471 | — | — | 2 | 5.88 |
| CHEMBL406103 | — | — | 2 | 5.68 |
| CHEMBL409316 | — | — | 2 | 5.67 |
| CHEMBL269893 | — | — | 2 | 5.55 |
| CHEMBL535396 | RIMANTADINE HYDROCHLORIDE | 4.0 | 2 | 5.15 |
| CHEMBL273132 | — | — | 1 | - |
| CHEMBL405896 | — | — | 1 | - |
| CHEMBL404602 | — | — | 1 | - |
| CHEMBL1569 | AMANTADINE HYDROCHLORIDE | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429426 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL270339 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL270260 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL271608 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL261602 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL270540 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL261601 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL273129 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL273131 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL270541 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL270471 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL406103 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL409316 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL269893 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL535396 | RIMANTADINE HYDROCHLORIDE | IC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL1569 | AMANTADINE HYDROCHLORIDE | IC90 | > | 132400.0 | nM | - |
| CHEMBL535396 | RIMANTADINE HYDROCHLORIDE | IC90 | = | 13970.0 | nM | - |
| CHEMBL270260 | — | IC90 | = | 540.0 | nM | - |
| CHEMBL269893 | — | IC90 | = | 5640.0 | nM | - |
| CHEMBL270339 | — | IC90 | = | 470.0 | nM | - |
| CHEMBL409316 | — | IC90 | = | 2810.0 | nM | - |
| CHEMBL273129 | — | IC90 | = | 1300.0 | nM | - |
| CHEMBL429426 | — | IC90 | = | 110.0 | nM | - |
| CHEMBL404602 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL1569 | AMANTADINE HYDROCHLORIDE | IC50 | > | 132400.0 | nM | - |
| CHEMBL270540 | — | IC90 | = | 1060.0 | nM | - |
| CHEMBL270541 | — | IC90 | = | 1650.0 | nM | - |
| CHEMBL273132 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL405896 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL270471 | — | IC90 | = | 1730.0 | nM | - |
| CHEMBL406103 | — | IC90 | = | 2650.0 | nM | - |
| CHEMBL261601 | — | IC90 | = | 1060.0 | nM | - |
| CHEMBL273131 | — | IC90 | = | 1980.0 | nM | - |
| CHEMBL261602 | — | IC90 | = | 670.0 | nM | - |
| CHEMBL271608 | — | IC90 | = | 670.0 | nM | - |