Assay Detail
ADMET
CHEMBL932840
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Inhibition of CYP3A4
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.50 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272693 | — | — | 1 | 7.00 |
| CHEMBL406388 | — | — | 1 | 5.70 |
| CHEMBL269915 | — | — | 1 | 4.89 |
| CHEMBL270978 | — | — | 1 | 4.40 |
| CHEMBL429743 | — | — | 1 | - |
| CHEMBL429585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272693 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL406388 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL269915 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL270978 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL429743 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL429585 | — | IC50 | > | 50000.0 | nM | - |