Assay Detail
Binding
CHEMBL932889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SERT
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.17 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 8.18 |
| CHEMBL256667 | — | — | 1 | 8.08 |
| CHEMBL260440 | — | — | 1 | 7.89 |
| CHEMBL410622 | — | — | 1 | 7.11 |
| CHEMBL415098 | — | — | 1 | 7.00 |
| CHEMBL406156 | — | — | 1 | 6.82 |
| CHEMBL256646 | — | — | 1 | 6.80 |
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 6.72 |
| CHEMBL260439 | — | — | 1 | 6.55 |
| CHEMBL259209 | MILNACIPRAN | 4.0 | 1 | 6.38 |
| CHEMBL272285 | — | — | 1 | 6.19 |
| CHEMBL269799 | — | — | 1 | 6.08 |
| CHEMBL256021 | — | — | 1 | 5.96 |
| CHEMBL256020 | — | — | 1 | 5.92 |
| CHEMBL272744 | — | — | 1 | 5.89 |
| CHEMBL402999 | — | — | 1 | 5.89 |
| CHEMBL256408 | — | — | 1 | 5.80 |
| CHEMBL256019 | — | — | 1 | 5.77 |
| CHEMBL404364 | — | — | 1 | 5.77 |
| CHEMBL256039 | — | — | 1 | 5.70 |
| CHEMBL1169524 | — | — | 1 | 5.66 |
| CHEMBL256447 | — | — | 1 | 5.51 |
| CHEMBL269798 | — | — | 1 | 5.50 |
| CHEMBL401621 | — | — | 1 | 5.46 |
| CHEMBL270569 | — | — | 1 | 5.36 |
| CHEMBL404474 | — | — | 1 | 5.36 |
| CHEMBL272286 | — | — | 1 | 5.32 |
| CHEMBL402365 | — | — | 1 | 5.27 |
| CHEMBL404345 | — | — | 1 | 5.12 |
| CHEMBL256841 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1175 | DULOXETINE | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL256667 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL260440 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL410622 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL415098 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL406156 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL256646 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL641 | ATOMOXETINE | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL260439 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL259209 | MILNACIPRAN | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL272285 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL269799 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL256021 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL256020 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL402999 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL272744 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL256408 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL256019 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL404364 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL256039 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1169524 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL256447 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL269798 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL401621 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL270569 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL404474 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL272286 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL402365 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL404345 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL272530 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL272790 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL450623 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL257048 | N,N-DIMETHYL MILNACIPRAN | IC50 | > | 10000.0 | nM | - |
| CHEMBL257047 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL270240 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL272074 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL404475 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL255839 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL272986 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL272531 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL256397 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL256841 | — | IC50 | > | 10000.0 | nM | - |