Assay Detail
Functional
CHEMBL933041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against human MCF7 cells after 4 hrs by MTT assay
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New homocamptothecins: synthesis, antitumor activity, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.69 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255332 | — | — | 1 | 8.52 |
| CHEMBL255120 | — | — | 1 | 7.46 |
| CHEMBL271466 | — | — | 1 | 6.36 |
| CHEMBL272726 | — | — | 1 | 6.31 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.31 |
| CHEMBL258121 | — | — | 1 | 6.31 |
| CHEMBL272724 | — | — | 1 | 6.29 |
| CHEMBL404149 | — | — | 1 | 6.25 |
| CHEMBL401635 | — | — | 1 | 6.07 |
| CHEMBL407463 | — | — | 1 | 6.07 |
| CHEMBL427894 | — | — | 1 | 5.94 |
| CHEMBL255217 | — | — | 1 | 5.87 |
| CHEMBL272055 | — | — | 1 | 5.70 |
| CHEMBL255187 | — | — | 1 | 5.63 |
| CHEMBL404712 | — | — | 1 | 5.56 |
| CHEMBL404838 | — | — | 1 | 5.45 |
| CHEMBL411872 | — | — | 1 | 5.40 |
| CHEMBL404573 | — | — | 1 | 5.36 |
| CHEMBL401755 | — | — | 1 | 5.23 |
| CHEMBL429573 | — | — | 1 | 5.18 |
| CHEMBL1202382 | — | — | 1 | 5.16 |
| CHEMBL270425 | — | — | 1 | 5.16 |
| CHEMBL404302 | — | — | 1 | 5.03 |
| CHEMBL271465 | — | — | 1 | 5.03 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 4.76 |
| CHEMBL404617 | — | — | 1 | 4.69 |
| CHEMBL255188 | — | — | 1 | 4.68 |
| CHEMBL429417 | — | — | 1 | 4.68 |
| CHEMBL272056 | — | — | 1 | 4.58 |
| CHEMBL272982 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255332 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL255120 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL271466 | — | IC50 | = | 441.0 | nM | 6.36 |
| CHEMBL272726 | — | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL258121 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL272724 | — | IC50 | = | 517.0 | nM | 6.29 |
| CHEMBL404149 | — | IC50 | = | 559.0 | nM | 6.25 |
| CHEMBL401635 | — | IC50 | = | 853.0 | nM | 6.07 |
| CHEMBL407463 | — | IC50 | = | 852.0 | nM | 6.07 |
| CHEMBL427894 | — | IC50 | = | 1154.0 | nM | 5.94 |
| CHEMBL255217 | — | IC50 | = | 1344.0 | nM | 5.87 |
| CHEMBL272055 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL255187 | — | IC50 | = | 2324.0 | nM | 5.63 |
| CHEMBL404712 | — | IC50 | = | 2763.0 | nM | 5.56 |
| CHEMBL404838 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL411872 | — | IC50 | = | 3943.0 | nM | 5.40 |
| CHEMBL404573 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL401755 | — | IC50 | = | 5882.0 | nM | 5.23 |
| CHEMBL429573 | — | IC50 | = | 6621.0 | nM | 5.18 |
| CHEMBL1202382 | — | IC50 | = | 6937.0 | nM | 5.16 |
| CHEMBL270425 | — | IC50 | = | 6847.0 | nM | 5.16 |
| CHEMBL271465 | — | IC50 | = | 9245.0 | nM | 5.03 |
| CHEMBL404302 | — | IC50 | = | 9291.0 | nM | 5.03 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 17403.0 | nM | 4.76 |
| CHEMBL404617 | — | IC50 | = | 20259.0 | nM | 4.69 |
| CHEMBL255188 | — | IC50 | = | 20855.0 | nM | 4.68 |
| CHEMBL429417 | — | IC50 | = | 20768.0 | nM | 4.68 |
| CHEMBL272056 | — | IC50 | = | 25994.0 | nM | 4.58 |
| CHEMBL255366 | — | IC50 | > | 20450.0 | nM | - |
| CHEMBL403643 | — | IC50 | > | 20720.0 | nM | - |
| CHEMBL271716 | — | IC50 | > | 19730.0 | nM | - |
| CHEMBL269993 | — | IC50 | > | 18750.0 | nM | - |
| CHEMBL255365 | — | IC50 | > | 21160.0 | nM | - |
| CHEMBL271665 | — | IC50 | > | 20450.0 | nM | - |
| CHEMBL255563 | — | IC50 | > | 20720.0 | nM | - |
| CHEMBL255425 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL401634 | — | IC50 | > | 19110.0 | nM | - |
| CHEMBL271875 | — | IC50 | > | 19880.0 | nM | - |
| CHEMBL270449 | — | IC50 | > | 21160.0 | nM | - |
| CHEMBL271891 | — | IC50 | > | 20720.0 | nM | - |
| CHEMBL403974 | — | IC50 | > | 19510.0 | nM | - |
| CHEMBL273133 | — | IC50 | > | 19510.0 | nM | - |
| CHEMBL404403 | — | IC50 | > | 19510.0 | nM | - |
| CHEMBL270211 | — | IC50 | > | 21340.0 | nM | - |
| CHEMBL411639 | — | IC50 | > | 20720.0 | nM | - |
| CHEMBL272982 | — | IC50 | > | 20720.0 | nM | - |