Assay Detail
Functional
CHEMBL933048
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Antiviral activity against HIV1 in MT4 cells by XTT assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 6.39 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 8.41 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 7.39 |
| CHEMBL429609 | — | — | 1 | 6.77 |
| CHEMBL270135 | — | — | 1 | 6.77 |
| CHEMBL273057 | — | — | 1 | 6.75 |
| CHEMBL406420 | — | — | 1 | 6.72 |
| CHEMBL405019 | — | — | 1 | 6.72 |
| CHEMBL405316 | — | — | 1 | 6.68 |
| CHEMBL272832 | — | — | 1 | 6.66 |
| CHEMBL539678 | — | — | 1 | 6.33 |
| CHEMBL442805 | — | — | 1 | 6.32 |
| CHEMBL269874 | — | — | 1 | 6.30 |
| CHEMBL405858 | — | — | 1 | 6.29 |
| CHEMBL407748 | — | — | 1 | 6.25 |
| CHEMBL272848 | — | — | 1 | 6.22 |
| CHEMBL271756 | — | — | 1 | 6.11 |
| CHEMBL272849 | — | — | 1 | 6.09 |
| CHEMBL259895 | — | — | 1 | 6.07 |
| CHEMBL270080 | — | — | 1 | 6.06 |
| CHEMBL405041 | — | — | 1 | 6.04 |
| CHEMBL273031 | — | — | 1 | 6.01 |
| CHEMBL437606 | — | — | 1 | 6.01 |
| CHEMBL405092 | — | — | 1 | 6.00 |
| CHEMBL270059 | — | — | 1 | 5.96 |
| CHEMBL271818 | — | — | 1 | 5.92 |
| CHEMBL259884 | — | — | 1 | 5.92 |
| CHEMBL442971 | — | — | 1 | 5.75 |
| CHEMBL436861 | — | — | 1 | - |
| CHEMBL405313 | — | — | 1 | - |
| CHEMBL438010 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5483011 | INDINAVIR | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL429609 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL270135 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL273057 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL406420 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL405019 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL405316 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL272832 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL539678 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL442805 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL269874 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL405858 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL407748 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL272848 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL271756 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL272849 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL259895 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL270080 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL405041 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL273031 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL437606 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL405092 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL270059 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL271818 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL259884 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL442971 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL436861 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL405313 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL438010 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL259039 | — | EC50 | > | 10000.0 | nM | - |